abstract：BACKGROUND:Cytokines do not only mediate responses to infection, but are also involved in behavioral and physiological responses to psychological stressors. IL-6 has received special attention in relation to the development of posttraumatic stress disorders and depression. OBJECTIVE:We tested effects of prior injectio...

journal_title：Neuropsychobiology

authors： Matsumoto T,Komori T,Yamamoto M,Shimada Y,Nakagawa M,Shiroyama T,Inui K,Okazaki Y

更新日期：2006-01-01 00:00:00

abstract：:Little information exists on the concentrations of recent antidepressants and their metabolites in cerebrospinal fluid (CSF). Using a stereoselective method, we measured plasma and CSF levels of mirtazapine (MIR), N-demethylmirtazapine and 8-OH-MIR in 3 depressed patients treated with racemic MIR (45 mg/day) for 4 wee...

journal_title：Neuropsychobiology

authors： Baumann P,Jonzier-Perey M,Paus E,Nikisch G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:So-called Porteus mazes are used to investigate prefrontal cortex (PFC) functioning in normal subjects and patients with different neuropsychiatric disorders. Here we present data confirming the involvement of the PFC for the first time by means of functional magnetic resonance imaging (fMRI). To minimize mo...

journal_title：Neuropsychobiology

authors： Kirsch P,Lis S,Esslinger C,Gruppe H,Danos P,Broll J,Wiltink J,Gallhofer B

更新日期：2006-01-01 00:00:00

abstract：:Suicide is one of the leading causes of death among adolescents worldwide. Studies on the seasonal pattern of youth suicides are rare and the results are very contradictory and heterogeneous. Generally, suicide methods affect the pattern of suicide seasonality. Shooting is the most common suicide method among Finnish ...

journal_title：Neuropsychobiology

authors： Lahti A,Räsänen P,Karvonen K,Särkioja T,Meyer-Rochow VB,Hakko H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:There is evidence that the nicotinic alpha7-acetylcholine receptor (alpha7-AChR) is involved in the pathophysiology of schizophrenia. Several neurotransmitter receptors, including alpha7-AChR, have been demonstrated on peripheral blood lymphocytes (PBL) and it has been suggested that these peripheral recepto...

journal_title：Neuropsychobiology

authors： Perl O,Strous RD,Dranikov A,Chen R,Fuchs S

更新日期：2006-01-01 00:00:00

abstract：:Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...

journal_title：Neuropsychobiology

authors： Yu YW,Tsai SJ,Hong CJ,Chen MC,Yang CW,Chen TJ

更新日期：2005-01-01 00:00:00

abstract：:Recent studies suggest that the eye blink response to intense acoustic stimuli consists of two components that may occasionally result in waveforms with two peaks. In the present study, the prevalence, peak latencies, and peak magnitudes in responses exhibiting one or two peaks were investigated in healthy subjects in...

journal_title：Neuropsychobiology

authors： Meincke U,Light GA,Geyer MA,Braff DL

更新日期：2005-01-01 00:00:00

abstract：:The focus is on evaluating the relationships between early behavioural problems and biochemical variables at adult age and their significance for early criminality and violent behaviour in a life perspective. In the present study, using prospective longitudinal data, a sample of males with a history of early criminal ...

journal_title：Neuropsychobiology

authors： Eklund J,Alm PO,af Klinteberg B

更新日期：2005-01-01 00:00:00

abstract：:The relationships between sensation seeking, curiosity about sex, and total and free testosterone in inmates were investigated. The role of other hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in these relationships was also analyzed. Previous ana...

journal_title：Neuropsychobiology

authors： Aluja A,García LF

更新日期：2005-01-01 00:00:00

abstract：:The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be re...

journal_title：Neuropsychobiology

authors： Bogacki PA,Borkowska A,Wojtanowska-Bogacka M,Rybakowski JK

更新日期：2005-01-01 00:00:00

abstract：:Two preliminary studies have indicated a variation in season of birth in severely language-disordered children. In the current study, the season of birth in 472 Danish children with language disorder born between 1958 and 1976 was compared with the season of birth of all Danish live-born children in the same period. F...

journal_title：Neuropsychobiology

authors： Hauschild KM,Mouridsen SE,Nielsen S

更新日期：2005-01-01 00:00:00

abstract：:Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...

journal_title：Neuropsychobiology

authors： Nunes Mamede Rosa ML,Nobre MJ,Ribeiro Oliveira A,Brandão ML

更新日期：2005-01-01 00:00:00

abstract：:Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirect...

journal_title：Neuropsychobiology

authors： Richardson MA,Read LL,Taylor Clelland CL,Reilly MA,Chao HM,Guynn RW,Suckow RF,Clelland JD

更新日期：2005-01-01 00:00:00

abstract：:The effects of zolpidem or zaleplon on sleep architecture, respiratory patterns and performance were assessed at a simulated altitude of 4,000 m. Twelve male healthy subjects spent 4 nights in a decompression chamber, 1 at sea level (baseline), 3 at 4,000 m to test zolpidem (10 mg), zaleplon (10 mg) and placebo, given...

journal_title：Neuropsychobiology

authors： Beaumont M,Batéjat D,Coste O,Van Beers P,Colas A,Clère JM,Piérard C

更新日期：2004-01-01 00:00:00

abstract：:There is increasing evidence for an influence of directed attention on prepulse inhibition (PPI) of the acoustic startle reflex. However, the existing paradigms for the assessment of this effect have methodological problems and pitfalls. In particular, most previous studies used a paradigm which directed the attention...

journal_title：Neuropsychobiology

authors： Heekeren K,Meincke U,Geyer MA,Gouzoulis-Mayfrank E

更新日期：2004-01-01 00:00:00

abstract：:This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients. Diffusion tensor imaging was performed on 8 late-life depressed patients and 12 healthy age-matched controls. The patients were scanned before and after a course of ECT. Fractio...

journal_title：Neuropsychobiology

authors： Nobuhara K,Okugawa G,Minami T,Takase K,Yoshida T,Yagyu T,Tajika A,Sugimoto T,Tamagaki C,Ikeda K,Sawada S,Kinoshita T

更新日期：2004-01-01 00:00:00

abstract：:To examine volumetric abnormality, the caudate nucleus was measured in patients with schizophrenia and healthy subjects using magnetic resonance imaging. The absolute and relative volumes of white matter in the caudate nucleus were found to be significantly smaller in patients with schizophrenia compared to those in h...

journal_title：Neuropsychobiology

authors： Takase K,Tamagaki C,Okugawa G,Nobuhara K,Minami T,Sugimoto T,Sawada S,Kinoshita T

更新日期：2004-01-01 00:00:00

abstract：:This study aimed to investigate the binding affinity of [3H]GABA and [3H]beta-alanine to GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex (Brodmanns' area 9) in schizophrenia. Using post mortem tissue from individuals diagnosed with schizophrenia (n=6) and control subjects (n=6), the densi...

journal_title：Neuropsychobiology

authors： Schleimer SB,Hinton T,Dixon G,Johnston GA

更新日期：2004-01-01 00:00:00

abstract：:Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...

journal_title：Neuropsychobiology

authors： Primavera A,Cocito L,Audenino D

更新日期：2004-01-01 00:00:00

abstract：:Human personality traits, which are substantially heritable, may be modulated by monoamine neurotransmitters. It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism that may affect monoamine metabolism, is possibly associated with specific person...

journal_title：Neuropsychobiology

authors： Tsai SJ,Hong CJ,Yu YW,Chen TJ

更新日期：2004-01-01 00:00:00

abstract：:Suicide is a major problem for psychiatry. Depression is the most common mental disorder related to suicidal behavior. The present study aimed at investigating the relationship between the symptomatology related to death, dying, and suicide and neurobiological factors in depressed patients. Fifty patients aged 21-60 y...

journal_title：Neuropsychobiology

authors： Fountoulakis KN,Iacovides A,Fotiou F,Nimatoudis J,Bascialla F,Ioannidou C,Kaprinis G,Bech P

更新日期：2004-01-01 00:00:00

abstract：:In the present study, the effects of short-acting benzodiazepines on nocturnal sleep and the carryover effects of these drugs were studied. The study involved 10 young, healthy male subjects who had given their written informed consent to participate. Either a placebo (PLA), 0.125 mg triazolam (TRZ), 0.25 mg TRZ or 0....

journal_title：Neuropsychobiology

authors： Suzuki H,Yamadera H,Asayama K,Kudo Y,Ito T,Tamura Y,Endo S

更新日期：2003-01-01 00:00:00

abstract：:In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...

journal_title：Neuropsychobiology

authors： Rodríguez-Landa JF,Contreras CM,Gutiérrez-García AG,Bernal-Morales B

更新日期：2003-01-01 00:00:00

abstract：:Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attention deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic...

journal_title：Neuropsychobiology

authors： Zoroglu SS,Erdal ME,Erdal N,Ozen S,Alasehirli B,Sivasli E

更新日期：2003-01-01 00:00:00

abstract：:It is known that P-4502E1 metabolizes both ethanol and acetaldehyde, and that it can be induced after birth by inducers such as ethanol. Genetic polymorphisms in the 5'-flanking region change its transcriptional regulation. Persons who are either hetereozygous or mutant homozygous for CYP2E1 (C1/C2 or C2/C2) can drink...

journal_title：Neuropsychobiology

authors： Nakamura K,Iwahashi K,Ameno K,Sekine Y,Suzuki K,Minabe Y,Mori N

更新日期：2003-01-01 00:00:00

abstract：:The peripheral blood platelets of schizophrenic patients were isolated, and the level of the platelet-associated antibodies (SPAA) was correlated with the rating scores of discrete schizophrenic symptom clusters evaluated with the Brief Psychiatric Rating Scale. Irrespective of medication and gender, symptom-dependent...

journal_title：Neuropsychobiology

authors： Sinyakov MS,Kessler B,Karp L,Weizman A,Kessler AR

更新日期：2003-01-01 00:00:00

abstract：:This study was aimed to test the association between schizophrenia and a functional serotonin polymorphism (5-HTTLPR) in the upstream regulatory region. Genomic DNA analysis with polymerase chain reaction was used for 5-HTTLPR genotyping. One hundred and eleven patients with schizophrenia and 208 healthy individuals p...

journal_title：Neuropsychobiology

authors： Pae CU,Kim JJ,Lee SJ,Lee CU,Lee C,Paik IH,Park HR,Yang S,Serretti A

更新日期：2003-01-01 00:00:00

abstract：:Genetic polymorphism of the serotonin 5-HT(2A) receptor seems to be associated with therapeutic response to selective serotonin reuptake inhibitors (SSRIs). The present study investigated whether a novel -1438G/A polymorphism in the promoter region of the 5-HT(2A )receptor gene is associated with therapeutic response ...

journal_title：Neuropsychobiology

authors： Sato K,Yoshida K,Takahashi H,Ito K,Kamata M,Higuchi H,Shimizu T,Itoh K,Inoue K,Tezuka T,Suzuki T,Ohkubo T,Sugawara K,Otani K

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this study was to investigate the relationship between postoperative confusion and the plasma norepinephrine (NE), adrenocorticotropin (ACTH) or cortisol response to surgery in schizophrenic patients. We studied 50 schizophrenic patients and 35 control patients who underwent orthopedic surgery and perio...

journal_title：Neuropsychobiology

authors： Kudoh A,Takahira Y,Katagai H,Takazawa T

更新日期：2002-01-01 00:00:00

abstract：:The growing number of studies examining the relationship between suicide and lipid metabolism are based upon studies suggesting that cholesterol-lowering procedures may increase the risk of death due to suicide or impulsive-aggressive behavior. Leptin seems to be strongly associated with lipid metabolism. In the prese...

journal_title：Neuropsychobiology

authors： Atmaca M,Kuloglu M,Tezcan E,Ustundag B,Gecici O,Firidin B

更新日期：2002-01-01 00:00:00

abstract：:Morningness-eveningness preference by the self-rated Morningness-Eveningness Questionnaire (MEQ) has earlier been shown to be associated with the subjects' season of birth. Here, we obtain this result for a new sample of 2,125 university students and for the sample obtained by pooling the data with the earlier study, ...

journal_title：Neuropsychobiology

authors： Natale V,Adan A,Chotai J

更新日期：2002-01-01 00:00:00

abstract：:Nitric oxide (NO) has been implicated to play a role in the pathogenesis of depressive disorders. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain, consistent with a role as neurotransmitter. Therefore, it...

journal_title：Neuropsychobiology

authors： Savaş HA,Herken H,Yürekli M,Uz E,Tutkun H,Zoroğlu SS,Ozen ME,Cengiz B,Akyol O

更新日期：2002-01-01 00:00:00

abstract：:Substance P (SP) is a neuropeptide which is abundant in the periphery and the central nervous system, where it is colocalized with other neurotransmitters such as serotonin or dopamine. SP has been proposed to play a role in the regulation of pain including migraine and fibromyalgia, asthma, inflammatory bowel disease...

journal_title：Neuropsychobiology

authors： Lieb K,Treffurth Y,Berger M,Fiebich BL

更新日期：2002-01-01 00:00:00

abstract：:Tardive dyskinesia caused by antipsychotic treatment is a severe problem not only in the management of schizophrenia, but also of affective disorders. Vitamin E monotherapy has been used in schizophrenic patients with tardive dyskinesia. Pharmacologists warn against high dosage of vitamin E because of its pro-oxidativ...

journal_title：Neuropsychobiology

authors： Michael N,Sourgens H,Arolt V,Erfurth A

更新日期：2002-01-01 00:00:00

abstract：:The serotonergic system has been implicated in the production of the N1 and P2 components of auditory evoked potentials (AEPs). Moreover, studies have indicated the influence of heritability in the genesis of these AEP components. The serotonin transporter is the major site of serotonin reuptake into the presynaptic n...

journal_title：Neuropsychobiology

authors： Chen TJ,Yu YW,Chen MC,Tsai SJ,Hong CJ

更新日期：2002-01-01 00:00:00

abstract：:Growth hormone (GH) possesses multiple metabolic effects, in particular with regard to glucose and lipid homeostasis. Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results. We investigated the effects of different modes of GH administration on the param...

journal_title：Neuropsychobiology

authors： Schulz C,Wieczorek I,Reschke K,Lehnert H

更新日期：2002-01-01 00:00:00

abstract：:Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...

journal_title：Neuropsychobiology

authors： Gouzoulis-Mayfrank E,Thelen B,Maier S,Heekeren K,Kovar KA,Sass H,Spitzer M

更新日期：2002-01-01 00:00:00

abstract：:Recent studies have suggested that synaptic abnormalities may be part of the pathophysiology of schizophrenia. SNAP-25 (synaptosomal-associated protein of 25 kD) is one of the synaptic proteins responsible for presynaptic neurotransmission, axonal elongation and synaptogenesis. Genetic variation in the 5'-upstream reg...

journal_title：Neuropsychobiology

authors： Tachikawa H,Harada S,Kawanishi Y,Okubo T,Suzuki T

更新日期：2001-01-01 00:00:00

abstract：:A potential candidate gene that could contribute to the education process is the apolipoprotein E (apo E) gene that has been shown to correlate with memory function and memory decline. We measured apo E polymorphism in groups of probands with different levels of education selected from a population sample. In the grou...

journal_title：Neuropsychobiology

authors： Hubacek JA,Pitha J,Skodová Z,Adámková V,Lánská V,Poledne R

更新日期：2001-01-01 00:00:00

abstract：:Serotonergic dysfunction is implicated in Alzheimer's disease (AD) on the basis of studies of serotonin and its metabolite in postmortem specimens and CSF. There were also reports on association of a tryptophan hydroxylase (TPH) intron 7 variant and CSF 5-hydroxyindoleacetic acid concentrations. These suggested TPH mi...

journal_title：Neuropsychobiology

authors： Wang YC,Tsai SJ,Liu TY,Liu HC,Hong CJ

更新日期：2001-01-01 00:00:00